Specific molecular allergic sensitisation patterns in pediatric polysensitised patients
نویسندگان
چکیده
Background Advances in the characterization of allergens have allowed the development of new diagnostic tools based on purified and recombinant allergens. The complex information provided by these multiplexed systems needs a careful interpretation in the light of the local characteristics of patients. Therefore, there is a need to define the sensitisation profiles of each population. The aim of the study was to define specific molecular allergic sensitisation patterns in pediatric polysensitised patients from the Mediterranean area (Barcelona).
منابع مشابه
Diagnosis and allergen immunotherapy treatment of polysensitised patients with respiratory allergy in Spain: an Allergists’ Consensus
BACKGROUND Polysensitisation is common in patients with respiratory allergy in Spain. Selection of the best allergen immunotherapy (AIT) is difficult in polysensitised patients. The present study was designed to help allergists better identify relevant allergens in these patients and to improve the selection of AIT in Spain. METHODS Sixty-two Spanish allergists answered a survey containing 88...
متن کاملInfluence of profilin on sensitisation profiles determined by cutaneous tests and IgE to major allergens in polysensitised patients
BACKGROUND Profilin sensitisation is considered a diagnostic confounding factor in areas where patients are exposed to multiple pollens. The aim of this study is to assess pollen sensitisation profiles in adults and children and to evaluate, by means of component-resolved diagnosis (CRD) and skin prick testing (SPT), which pollens may be considered as risk factors of profilin sensitisation in o...
متن کاملItraconazole as 'bridge therapy' to anti-IgE in a patient with severe asthma with fungal sensitisation.
Sensitisation to fungi has been reported to play an important role in a particular phenotype of severe asthma, the so-called severe asthma with fungal sensitisation, characterised by high levels of total IgE, which may be an obstacle to anti-IgE therapy. We describe here the case of a polysensitised woman with refractory asthma, sensitised to Aspergillus fumigatus with high total IgE values (17...
متن کاملExhaled nitric oxide levels in non-allergic and allergic mono- or polysensitised children with asthma.
BACKGROUND Increased fractional exhaled NO concentrations (FENO) and blood/tissue eosinophilia are frequently reported in allergic children with mild asthma and are thought to reflect the intensity of the inflammation characterising the disease. The aim of this study was to investigate possible differences in FENO levels or in the intensity of the blood eosinophilia in allergic and non-allergic...
متن کاملTolerability to dogfish in children with fish allergy.
BACKGROUND Fish is a potent food allergen. The aim of this work is to demonstrate that dogfish, a small shark, has low allergenicity in both its clinical tolerance as well as its molecular structure. METHODS We present a study of 34 paediatric patients with IgE-mediated immediate reactions after eating fish. The diagnosis of several fish allergies was demonstrated by skin prick techniques and...
متن کامل